뇌질환의 혁신, 뉴로벤티(NeuroVenti)

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Oxytocin receptor is not required for social attachment in prairie vol…

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조회 1,127회 작성일 23-01-29

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Prairie voles are among a small group of mammals that display long-term social attachment between mating partners. Many pharmacological studies show that signaling via the oxytocin receptor (Oxtr) is critical for the display of social monogamy in these animals. We used CRISPR mutagenesis to generate three different Oxtr-null mutant prairie vole lines. Oxtr mutants displayed social attachment such that males and females showed a behavioral preference for their mating partners over a stranger of the opposite sex, even when assayed using different experimental setups. Mothers lacking Oxtr delivered viable pups, and parents displayed care for their young and raised them to the weanling stage. Together, our studies unexpectedly reveal that social attachment, parturition, and parental behavior can occur in the absence of Oxtr signaling in prairie voles.


Reference: Berendzen KM, Sharma R, Mandujano MA, Wei Y, Rogers FD, Simmons TC, Seelke AMH, Bond JM, Larios R, Goodwin NL, Sherman M, Parthasarthy S, Espineda I, Knoedler JR, Beery A, Bales KL, Shah NM, Manoli DS. Oxytocin receptor is not required for social attachment in prairie voles. Neuron. 2022 Dec 28:S0896-6273(22)01084-4. doi: 10.1016/j.neuron.2022.12.011.